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Documentation

How to read a Certificate of Analysis

A line-by-line walkthrough of the COA we ship with every lot — what each field means and which numbers actually matter for your bench work.

Identity

The Identity block confirms the molecule by mass spectrometry. The reported mass should match the published monoisotopic or average mass of the molecule, within the stated tolerance of the analytical method.

Purity (HPLC)

HPLC purity is reported as area-percent. Our standards report ≥ 99% on most lots. The COA also lists the column, gradient, and detector wavelength, so you can replicate the run on your own analytical chain.

Water content and residual solvents

  • Water content (Karl Fischer): matters for stoichiometric work — high water content shifts the effective mass per vial.
  • Residual solvents: reports any acetonitrile, TFA, or DMF carried over from synthesis or freeze-drying.

Lot, expiry, and signatures

The lot number ties the vial to the analytical run. The expiry is conservative for the sealed vial under recommended storage. The lab signature identifies the independent analytical partner that ran the confirmation.

In-vitro research only

This article is reference material for qualified research professionals. It is not medical, clinical, or diagnostic guidance. Reference standards are sold for in-vitro characterisation only.

Continue reading
Handling and storage of lyophilized reference standards
How to keep a sealed reference vial stable from receiving dock to bench, and what changes once you reconstitute it.
Reconstitution basics: math, diluents, and aliquotting
The arithmetic behind preparing a working stock from a lyophilized reference vial, and why aliquotting is worth the extra ten minutes.
Lab safety etiquette around reference standards
PPE, fume-hood protocol, waste handling, and incident-response habits that keep a reference-standard bench safe and reproducible.
Glossary: terms you will see on a COA and in catalog copy
Quick definitions for COA, lyophilizate, HPLC, MS, BAC water, and other terms that show up across the catalog.